Self-Help opens with a political argument: the worth of a state is the worth of the individuals composing it. Smiles contends that legislation and institutions are negative and restrictive by nature; they can protect the fruits of industry but cannot supply the will to labour. The collective character of a nation is nothing but the sum of personal characters, so that lasting reform must begin not in Parliament but in the individual.
The long middle of the book, with chapters on inventors, potters, artists, men of business, and members of the peerage who rose from humble trades, functions as sustained biography. Smiles does not argue from abstract principle but from lives: Arkwright the barber who invented the spinning-frame, Wedgwood the potter who remade English earthenware, Watt the instrument-maker who perfected the steam-engine, Faraday the bookbinder's apprentice who became Britain's greatest experimental scientist. The cumulative lesson is that patient, repeated effort accomplishes what inheritance and circumstance cannot.
The chapter on application and perseverance draws the argument together explicitly. Genius, Smiles suggests, may be nothing more than common sense intensified, or, in Buffon's phrase, simply patience. Newton kept subjects continually before his mind until the first dawnings opened into full light. The man who lacks the gift of continuance is outstripped in the race of life by the diligent and even the dull. Facility comes only by repetition, and great results are achieved step by step rather than at a stroke.
Helps and Opportunities extends the theme: there are no purely accidental discoveries, only opportunities improved by prepared minds. Smiles shows how the smallest observations (a spider's web, a lobster shell, a soap bubble) led great inventors to practical breakthroughs because they had already spent years in patient thought on the relevant subject. The rude tools of many great workers, the improvised instruments and cramped workshops, demonstrate that it is not the facility but the trained man himself that matters.
The book closes on character and the True Gentleman. Character is power in a deeper sense than knowledge is power, for cleverness without goodness may serve only for mischief. The true gentleman is defined by self-respect, truthfulness, integrity, and a kind consideration for all below him in station. Riches and rank have no necessary connection with these qualities; the poorest man who retains courage, honesty, and self-respect is richer in the things that last than any man of wealth who lacks them.