The book is a collection of twelve self-contained cases narrated by Doctor Watson, Holmes's friend and lodger, looking back on the work of the consulting detective he shares rooms with in Baker Street. Each story brings a visitor with a problem the official police cannot or will not untangle, and Holmes solves it largely by reasoning from physical detail.
The opening tale, A Scandal in Bohemia, sets the keynote. A king fears an old photograph in the hands of the adventuress Irene Adler will wreck his marriage. Holmes tricks his way into learning where the picture is hidden, but Adler sees through him, slips away, and keeps the photograph, so that the great reasoner is for once outmanoeuvred by a clever woman.
Other cases turn equally ordinary surfaces into mysteries. In The Red-Headed League a pawnbroker is paid a strange salary to copy out an encyclopaedia, a scheme Holmes unmasks as cover for a bank tunnel. A governess, a missing stepfather, a country squire's death, and a band of vengeful strangers each yield to the same patient method of noticing what others pass over.
Across the stories Holmes repeatedly explains his craft to Watson and the reader. He distinguishes seeing from observing, deduces histories from a watch or a hat, and refuses to theorise until he has the facts, since data without evidence is bricks without clay. Watson plays the admiring witness whose ordinary perception measures how unusual Holmes's really is.
Taken together the adventures present detection as a kind of applied reasoning practised on everyday material. The settings are domestic and respectable, the clues small, and the solutions arrived at by chains of inference that Holmes makes look obvious only after the fact. The figure that emerges is brilliant, restless, and proud, formidable in method yet not beyond being surprised.