Buck is a powerful crossbred dog who reigns over Judge Miller's estate in the warm Santa Clara Valley, living the life of a contented country gentleman. He knows nothing of the Klondike gold strike of 1897, which has set thousands of men rushing north and made strong, furry dogs valuable. Betrayed and sold by a gardener's helper to pay gambling debts, Buck is roped, crated, and shipped into the frozen North.
On the Dyea beach he is jerked from the heart of civilization into the heart of things primordial. A club teaches him that he cannot beat a man who wields one, and the killing of a friendly dog named Curly teaches him the law of the place: once down, you are finished. Put into harness as a sled dog carrying government despatches, Buck learns the work quickly and begins to feel old instincts stir.
A bitter rivalry grows between Buck and Spitz, the experienced lead dog. It builds across the trail until the two fight in a watching circle of huskies, and Buck, fighting by head as well as by instinct, kills Spitz and takes his place at the head of the team. Through a punishing succession of owners and overloaded sleds, Buck hardens further, while memories of his heredity make an older, wilder world feel familiar to him.
Sold at last to reckless newcomers who drive the exhausted dogs onto rotten spring ice, Buck refuses to rise and is being beaten when John Thornton cuts him free. The others and the sled break through the ice and are lost. Nursed back to strength, Buck knows for the first time a genuine, passionate love, and he repays it with feats of devotion, even winning a wager by starting a thousand-pound load.
Thornton's earnings fund a journey deep into the wilderness after a fabled lost mine. There Buck answers a call from the forest, running for days with a wild wolf brother, drawn ever further from the fire. When a band of Yeehats kills Thornton and his partners, the last tie binding Buck to man is broken. He destroys the attackers, joins a wolf pack, and passes into legend as a ghostly dog running at the head of the pack.